New Homepage
Welcome to the new ChromDB homepage. We will be featuring ChromDB tools and reports in this space for
our future updates. For this update we are focusing on the types of sequences and organisms presented
displayed at ChromDB. Three types of sequences are included in the database: genomic-based
(predominantly plant sequences); transcript-based (EST contigs or cDNAs for plants lacking a sequenced
genome); and NCBI RefSeq sequences for a variety of model animal organisms. The Gene Record Page for
any sequence indicates the type of sequence. Click on the names of the organisms presented below to see examples of
these sequences.
Featured Researchers
Dr. Marjori Matzke and Dr. Antonius Matzke
Research interests:
Our lab has a long standing interest in epigenetic gene silencing in plants. In early experiments, we discovered a
homology- dependent gene silencing phenomenon in which a trans-acting,
sequence-specific signal triggered promoter methylation and
transcriptional gene silencing.
More...
Website News
New Protein Group Releases: Dek group: The human DEK protein is an abundant chromatin protein that is linked with cancers and
autoimmune disease. Hu et al. 2007 (PMID: 17524367) have shown DEK accumulates at promoter/enhancers of some actively transcribed genes but is mostly
excluded from heterochromatin. DEK homologous sequences are found in plants, but these proteins lack the Pfam
SAP domain found in the animal proteins.
Request for questions:
We want to accumulate a series of frequently asked questions to aid users in
navigating through the website and using the ChromDB tools. Please submit questions to the FAQ link
Upcoming releases: We are currently analyzing predicted proteins for
Sorghum bicolor and
Selaginella moellendorffii. We will release these annotations after we finish our intial analyses to
check the accuracy of the predicted models from the Joint Genome Institute.
